Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

Marine Drugs

Bin Wu¹  Vanessa Oesker¹  Jutta Wiese¹  Rolf Schmaljohann¹ 

[1] Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany; E-Mails:

关键词: pyridones;    antibiotic;    Trichoderma;    marine fungus;   

DOI  :  10.3390/md12031208

来源: mdpi

【 摘 要 】

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC₅₀ values of 24 μM and 4 μM, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.