Advances in Testing Techniques for Digital Microfluidic Biochips

Sensors

Noohul Basheer Zain Ali¹  Fawnizu Azmadi Hussin¹  Vineeta Shukla²  Nor Hisham Hamid² 

[1] Electronic Engineering Department, Centre for Intelligent Signal and Imaging Research (CISIR), Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia;;Electrical &

关键词: digital microfluidics;    testing;    reliability;    MEDA;    droplet;    biochips;   

DOI  :  10.3390/s17081719

来源: DOAJ

【 摘 要 】

With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA)-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips.

【 授权许可】

Unknown