Primary malignant melanoma of the esophagus treated with subtotal esophagectomy: a case report

BMC Surgery

Yuma Ebihara¹  Toshimichi Asano¹  Toru Nakamura¹  Takahiro Tsuchikawa¹  Takehiro Noji¹  Yo Kurashima¹  Soichi Murakami¹  Keisuke Okamura¹  Satoshi Hirano¹  Shota Kuwabara¹  Toshiaki Shichinohe¹  Yoshitsugu Nakanishi¹ 

[1] Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine;

关键词: Esophagus;    Melanoma;    Pathology;    Treatment;    Prognosis;   

DOI  :  10.1186/s12893-017-0326-7

来源: DOAJ

【 摘 要 】

Abstract Background Primary malignant melanoma of the esophagus (PMME) is a rare disease with a poor prognosis. There are few reports of early-stage cases in which tumor invasion reached the lamina propria or muscularis mucosae, as in the present case. A standard treatment for early-stage PMME has not yet been established. The present study aimed to summarize previous reports and to discuss the indications for surgical treatment of early-stage primary malignant melanoma of the esophagus. Case presentation A 70-year-old woman with PMME was referred to our hospital. She underwent thoracoscopic and laparoscopic subtotal esophagectomy with lymphadenectomy. The resected specimen showed melanocytosis and junctional activity. Melanoma-specific antigens melan-A, S-100, and HMB45 were detected by immunohistochemical staining. The pathological diagnosis was pT1a-MM, pN0, pM0, and pStage IA. She remains alive without evidence of recurrence 39 months later. Conclusion Subtotal esophagectomy with regional radical lymphadenectomy could be recommended to patients with early-stage primary malignant melanoma of the esophagus, and curative surgical resection could improve their prognosis.

【 授权许可】

Unknown