The Evolutionary Dynamics of Cancer

Maley, Carlo C.

Fred Hutchinson Cancer Research Center

关键词: Neoplasms;    59 Basic Biological Sciences;    Mutations;    Mutants;    Esophagus;   

DOI  :  10.2172/842847
RP-ID  :  NONE
RP-ID  :  FG03-00ER62981
RP-ID  :  842847

美国|英语

来源: UNT Digital Library

【 摘 要 】

We hypothesized that a subset of the mutations observed in the progression to cancer confer beneficial selective effects on the cell. Our aim was to identify these selective mutations and to infer the interactions between the mutant clones in Barrett's esophagus (BE) that eventually lead to the development of esophageal adenocarcinoma. The results were to be a set of predictions about the roles of specific mutations in the progression to cancer.