Rapid Nucleic Acid Analysis for Contaminant Impact Evaluation

Chen, Winston Chung-Hsuan

Oak Ridge National Laboratory

关键词: Dna;    Nucleic Acids;    59 Basic Biological Sciences;    Mutations;    Detection;   

DOI  :  10.2172/839370
RP-ID  :  EMSP-73807--2001
RP-ID  :  839370

美国|英语

来源: UNT Digital Library

【 摘 要 】

The objective of this program is to develop innovative DNA detection technologies to achieve fast mutation screening and to reveal the linkage between gene mutation and contaminants. The specific approach are (1) to develop innovative multiplexing hybridization detection for DNA mutation detection, (2) to develop sequence-proof microarray hybridization technology (3) to develop hybridization on disk and (4) to apply these new DNA detection technology for mutation analysis of contaminated fish and to validate the pollution-mediated mutation can be used for sound risk analysis for setting up the priorities for waste cleanup.