Primary amelanotic malignant melanoma of the esophagus: a case report

Surgical Case Reports

Yutaka Koga¹  Yoshinao Oda¹  Kosuke Hirose²  Nobuhide Kubo²  Hiroshi Saeki²  Shun Sasaki²  Yuichiro Nakashima²  Eiji Oki²  Tomoko Jogo²  Naomichi Koga²  Yoshihiko Maehara³  Hisao Oiwa⁴  Toshio Oiwa⁴ 

[1] Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University;Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University;Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers;Oiwa Gastrointestinal Clinic;

关键词: Esophagus;    Amelanotic melanoma;    Diagnosis;    Prognosis;    Pathology;   

DOI  :  10.1186/s40792-019-0564-2

来源: DOAJ

【 摘 要 】

Abstract Background Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME. Case presentation An 86-year-old woman was admitted to our hospital with symptoms of dysphagia. An endoscopic examination and constructed radiography revealed an elevated and semipedunculated lesion with an ulcer in the lower thoracic esophagus accompanied by another submucosal lesion of the esophagus. She was diagnosed with esophageal squamous cell carcinoma by a preoperative endoscopic biopsy. We performed thoracoscopy- and laparoscopy-assisted subtotal esophagectomy with lymphadenectomy. Based on the surgical specimens, although there were no melanocytes, we made a diagnosis of a malignant melanoma immunohistochemically; the tumor cells were positive for S-100 protein and HMB45 focally and partially for Melan-A. Conclusion We experienced a case of primary amelanotic malignant melanoma, and the patient has remained disease-free for 1 year since the surgery. Since the diagnosis of amelanotic type of PMME is difficult, it should be made by the combination of a morphological examination, pathological examination, and immunohistochemistry.

【 授权许可】

Unknown