Design, Fabrication, and Packaging of an Integrated, Wirelessly-Powered Optrode Array for Optogenetics Application

Frontiers in Systems Neuroscience

Hyung-Min eLee¹  Maysam eGhovanloo¹  Wen eLi²  Arthur eWeber²  Ki Yong eKwon² 

[1] Georgia Institute of Technology;Michigan State University;

关键词: optogenetics;    Microelectromechanical Systems;    Wireless power transfer;    optrode array;    implantable neural interface;    switched-capacitor based stimulators;   

DOI  :  10.3389/fnsys.2015.00069

来源: DOAJ

【 摘 要 】

The recent development of optogenetics has created an increased demand for advancing engineering tools for optical modulation of neural circuitry.This paper details the design, fabrication, integration, and packaging procedures of a wirelessly-powered, light emitting diode (LED) coupled optrode neural interface for optogenetic studies.The LED-coupled optrode array employs microscale LED (μLED) dies and polymer-based microwaveguides to deliver light into multi-level cortical networks, coupled with microelectrodes to record spontaneous changes in neural activity.An integrated, implantable, switched-capacitor based stimulator (SCS) system provides high instantaneous power to the μLEDs through an inductive link to emit sufficient light and evoke neural activities.The presented system is mechanically flexible, biocompatible, miniaturized, and lightweight, suitable for chronic implantation in small freely behaving animals.The design of this system is scalable and its manufacturing is cost effective through batch fabrication using microelectromechanical systems (MEMS) technology.It can be adopted by other groups and customized for specific needs of individual experiments.

【 授权许可】

Unknown