Engineering the Interface Between Inorganic Materials and Cells

Schaffer, David

关键词: materials engineering;    cell-material interface;    light;    optogenetics;   

DOI  :  10.2172/1143936
RP-ID  :  DE-SC0001216
PID  :  OSTI ID: 1143936

学科分类：材料科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

To further optimize cell function in hybrid ???living materials???, it would be advantageous to render mammalian cells responsive to novel ???orthogonal??? cues, i.e. signals they would not ordinarily respond to but that can be engineered to feed into defined intracellular signaling pathways. We recently developed an optogenetic method, based on A. thaliana Cry2, for rapid and reversible protein oligomerization in response to blue light. We also demonstrated the ability to use this method to channel the light input into several defined signaling pathways, work that will enhance communication between inorganic devices and living systems.