Long-term administration of protein hydrolysate from chicken feet induces antihypertensive effect and confers vasoprotective pattern in diet-induced hypertensive rats

Journal of Functional Foods

Francisca I. Bravo¹  Manuel Suarez²  Lisard Iglesias-Carres²  Anna Mas-Capdevila²  Anna Arola-Arnal²  Begoña Muguerza² 

[1] EURECAT-Technology Centre of Catalonia, Technological Unit of Nutrition and Health, Reus, Spain;Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Nutrigenomics Research Group, Tarragona, Spain;

关键词: Bioactive peptides;    Cafeteria diet;    Metabolic syndrome;    Endothelial function;    Protein hydrolysate;   

DOI  :  

来源: DOAJ

【 摘 要 】

The aim of this study was to evaluate the effect of long-term administration of the protein hydrolysate from chicken feet Hpp11 in diet-induced hypertensive rats. Rats were fed standard or cafeteria (CAF) diets for 12 weeks, and during the final 3 weeks, CAF animals were administered vehicle, Captopril or Hpp11. Systolic blood pressure (SBP) was recorded weekly. Body weight and plasmatic lipid and glucose levels were determined. Moreover, liver-reduced glutathione (GSH) levels, plasmatic angiotensin converting enzyme (ACE) activity and the endothelial gene expression of eNOS, KLF-2, Sirt-1, NOX4 and ET-1 were studied. A definite decrease in SBP was recorded in the rats that were administered Hpp11. Hpp11 downregulated gene expression of the vasoconstrictor ET-1 and induced the upregulation of NOX4 and NO enhancer Sirt-1, suggesting the vasoprotective effect of Hpp11. Moreover, Hp11 increased hepatic GSH. The present findings suggest that Hpp11 is a good candidate to ameliorate diet-induced hypertension.

【 授权许可】

Unknown