Identification and Characterization of Bioactive Peptides of Fermented Goat Milk as a Sources of Antioxidant as a Therapeutic Natural Product

International Conference on Chemistry and Material Science 2017

化学;材料科学

Mahdi, Chanif^1 ; Untari, Handayu^2 ; Padaga, Masdiana Cendrakasih^3

Department of Chemistry, Faculty of Sciences, Brawijaya University, Malang, Indonesia^1

Veterinary Medicinal Faculty, Brawijaya University, Malang, Indonesia^2

Veterinary Medicinal Program, Brawijaya University, Malang, Indonesia^3

关键词: Anti-hypertension;    Bioactive peptides;    Dietary treatments;    Fermented goat milks;    Hypercholesterolemia;    Immuno modulators;    Natural products;    Regulatory functions;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/299/1/012014/pdf
DOI  :  10.1088/1757-899X/299/1/012014

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

The increasing of functional food is rising in line with public awareness for healthy food consumption. Provision of functional food source is developed through enhanced bioactive that has a regulatory function for body. Bioactive peptides in milk is known have variety of beneficial function of the body such as immunomodulator, immunostimulatory, anti-hypertension, anti-hyper cholesterol, as well as a variety of other beneficial function. The aim of this study is to obtain fermentation methods to product functional dairy product contain bioactive peptides and beneficial of fermented goat milk. The result of this study showed that goat milk fermented using 3 % commercial starter able to produce the best yoghurt than using local yoghurt starter. Analysis of protein content showed that the fermentation processing increased the amount of protein in goat milk sample. Using SDS-PAGE showed that the breakdown of protein into fraction of fermented goat milk greater than unfermented goat milk. The result of fractional protein was analyzed by LC MS/MS and showed that there were three kind bioactive sequences of bioactive peptides. Each of which consist of 16 amino acids that safely protected from gastrointestinal animal model that fed by dietary treatment of hypercholesterolemia.