Gamma radiation-induced synthesis and characterization of Polyvinylpyrrolidone nanogels

8th International Congress of Engineering Physics

物理学;工业技术

Ges, A.A.^1 ; Viltres, H.^1,2 ; Borja, R.^3 ; Rapado, M.^4 ; Aguilera, Y.^1

Instituto Superior de Tecnologías y Ciencias Aplicadas, Departamento de Radioquímica, La Habana, Cuba^1

Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada-Unidad Legaria, Instituto Politécnico Nacional, Ciudad de México, Distrito Federal, Mexico^2

Centro de Nanociencias y Micro-Nanotecnologías, Instituto Politécnico Nacional, Ciudad de México, Distrito Federal, Mexico^3

Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, La Habana, Cuba^4

关键词: Bioactive peptides;    Characterization techniques;    Crosslinking reaction;    Gamma irradiation;    Polymeric devices;    Polyvinyl pyrrolidone;    Potential systems;    Radiation-induced synthesis;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/792/1/012080/pdf
DOI  :  10.1088/1742-6596/792/1/012080

学科分类：工业工程学

来源: IOP

【 摘 要 】

Due to the importance of bioactive peptides, proteins and drug for pharmaceutical purpose, there is a growing interest for suitable delivery systems, able to increase their bioavailability and to target them to the desired location. Some of the most studied delivery systems involve encapsulation or entrapment of drugs into biocompatible polymeric devices. A multitude of techniques have been described for the synthesis of nanomaterials from polymers, however, the use of ionizing radiation (γ, e-), to obtain nano- and microgels polymer is characterized by the possibility of obtaining products with a high degree of purity. Although, in the world, electronic radiation is used for this purpose, gamma radiation has not been utilized for these purposes. In this paper is developed the formulation the formulation of Polyvinylpyrrolidone (PVP) nanogels synthesized by gamma radiation techniques, for their evaluation as potential system of drug delivery. Experiments were performed in absence of oxygen using aqueous solutions of PVP (0.05% -1%). Crosslinking reactions were carried out at 25° C in a gamma irradiation chamber with a60Co source (MPX-γ 30). The Viscosimetry, Light Scattering, X-Ray Diffraction and Transmission Electron Microscopy (TEM), were used as characterization techniques.