Blend membrane of succinic acid-crosslinked chitosan grafted with heparin/PVA-PEG (polyvinyl alcohol-polyethylene glycol) and its characterization

12th Joint Conference on Chemistry

Sangkota, V.D.A.^1 ; Lusiana, R.A.^2 ; Astuti, Y.^2

Post Graduate Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Diponegoro, Semarang

50275, Indonesia^1

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Diponegoro, Semarang

50275, Indonesia^2

关键词: Blend membranes;    Cross linked chitosan;    Crosslinking reaction;    Grafting reactions;    Hemodialysis membranes;    Material compositions;    Membrane hydrophilicity;    Modified materials;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/349/1/012065/pdf
DOI  :  10.1088/1757-899X/349/1/012065

来源: IOP

【 摘 要 】

Crosslinking and grafting reactions are required to modify the functional groups on chitosan to increase the number of its active groups. In this study, crosslinking reaction of succinic acid and grafting reaction of heparin on chitosan were conducted to produce a membrane as a candidate of a hemodialysis membrane. The mole ratio between chitosan and succinate acids was varied to obtain the best composition of modified materials. By blending all the material composition with PVA-PEG, the blend was transformed into a membrane. The resulted membrane was then characterized by various test methods such as tests of thickness, weight, water uptake, pH resistance, tensile strength and membrane hydrophilicity. The results showed that the best composition of the membrane reached in the addition of 0.011 gram of succinic acid proved by its highest mechanical strength compared to the other membranes.