Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Deepak Saxena¹  Smruti Pushalkar¹  Patricia M. Corby²  Angela R. Kamer³  Kumar Raghava Chowdary Annam³  Deepthi Gulivindala³  Henrik Zetterberg⁴  Kaj Blennow⁴  Tracy Butler⁵  Yi Li⁵  Lidia Glodzik⁵  Mony J. deLeon⁵  Karla V. Ballman⁶ 

[1] Department of Molecular Pathobiology College of Dentistry New York University New York USA;Department of Oral Medicine School of Dental Medicine University of Pennsylvania Philadelphia Pennsylvania USA;Department of Periodontology and Implant Dentistry College of Dentistry New York University New York USA;Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden;Department of Radiology Weill Medical Center Brain Health Imaging Institute Cornell University New York USA;Division of Biostatistics Department of Population Health Sciences Weill Medical Center Weill Cornell Medicine New York USA;

关键词: 16S rRNA sequencing;    Alzheimer's disease;    amyloid;    CSF biomarkers;    infection;    normal aging;   

DOI  :  10.1002/dad2.12172

来源: DOAJ

【 摘 要 】

Abstract Introduction Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome. Methods A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria to healthy bacteria. Analysis of variance/analysis of covariance (ANOVA/ANCOVA), linear discriminant effect‐size analyses (LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups. Results At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 (P = 0.02 and 0.01) but not with P‐tau. Discussion We show a selective relationship between periodontal disease bacterial dysbiosis and CSF biomarkers of amyloidosis, but not for tau. Further modeling is needed to establish the direct link between oral bacteria and Aβ.

【 授权许可】

Unknown