Exacerbated CSF abnormalities in younger patients with Alzheimer's disease

Neurobiology of Disease

卷:54

Stéphanie Bombois¹  Sylvain Lehmann²  Claire Paquet²  Audrey Gabelle³  Katell Peoc'h⁴  Jean-Louis Laplanche⁵  Susanna Schraen⁵  Olivier Vercruysse⁶  Julien Dumurgier⁷  Jacques Hugon⁸  Jacques Touchon⁸  Bernard Sablonnière⁹  Florence Pasquier⁹ 

[1] Biochimie-Protéomique Clinique, IRB, CCBHM, INSERM U1040, University of Montpellier, Montpellier, France;

[2] Centre de Biologie Pathologie UF de Neurobiologie, Lille University Hospital, Lille, France;

[3] Corresponding author at: Centre Mémoire Ressources Recherche Paris Nord Ile-de-France, Lariboisière, Fernand Widal Hospital, 200 rue du Faubourg-Saint-Denis, 75010 Paris, France. Fax: [phone].;

[4] INSERM U837, University Lille-Nord de France, Jean-Pierre Aubert Research Center, Lille, France;

[5] Centre Mémoire Ressources Recherche Lille, EA 1046, Lille University Hospital, Lille, France;

[6] Centre Mémoire Ressources Recherche Montpellier, University of Montpellier, Montpellier, France;

[7] Centre Mémoire Ressources Recherche Paris Nord Ile-de-France, Saint Louis-Lariboisiere, Fernand Widal Hospital, AP-HP, University Paris 7-Denis Diderot, Paris, France;

[8] Service de Biochimie et Biologie Moléculaire, Saint Louis, Lariboisière, Fernand Widal Hospital, AP-HP, PRES Sorbonne, Paris Cité, Paris, France;

关键词: Alzheimer's disease;    CSF biomarkers;    Age factor;    Epidemiology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Increasing age is the most important risk factor for developing Alzheimer's disease (AD). The aim of this study was to investigate the relationships between age and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ 1–42), total Tau and phosphorylated Tau (pTau-181), in AD and non-AD patients explored for cognitive disorders. 966 patients (AD, n=528; non-AD, n=438) were included between January 2008 and December 2010 (mean age, 69.5 years; mean MMSE, 20.2) from three French memory centers. Multivariable linear regression models were used to study the relationship between CSF biomarker levels and age in AD and non-AD patients. The capacity of each CSF biomarker in discriminating patients was evaluated using the area under the receiver-operating characteristic (ROC) curves by quartile of distribution of age. In AD patients, older age was associated with higher CSF Aβ 1–42 and lower Tau levels. Conversely, in non-AD patients, age was associated with lower CSF Aβ 1–42, higher Tau, and higher pTau-181 levels. In sex-stratified analysis, these relationships were significant only in women. Using ROC curve analysis, CSF AD biomarkers were more discriminant in younger patients than in older ones. In this clinically-based study, younger patients with AD had exacerbated CSF anomalies compared to older patients with AD. CSF biomarkers were more discriminant in younger patients than in older ones for the diagnosis of AD, especially in women. These results support the idea of an overlap in AD neuropathological lesions in oldest subjects with or without AD.

【 授权许可】

Unknown