The Counteracting Effects of Exercise on High-Fat Diet-Induced Memory Impairment: A Systematic Review

Brain Sciences

Hong Li¹  Pamela Ponce¹  Liye Zou²  PaulD. Loprinzi² 

[1] Memory Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, Oxford, MS 38677, USA;;Exercise &

关键词: cytokines;    hippocampal neurogenesis;    inflammation;    insulin resistance;    obesity;   

DOI  :  10.3390/brainsci9060145

来源: DOAJ

【 摘 要 】

The objective of the present review was to evaluate whether exercise can counteract a potential high-fat diet-induced memory impairment effect. The evaluated databases included: Google Scholar, Sports Discus, Embase/PubMed, Web of Science, and PsychInfo. Studies were included if: (1) an experimental/intervention study was conducted, (2) the experiment/intervention included both a high-fat diet and exercise group, and evaluated whether exercise could counteract the negative effects of a high-fat diet on memory, and (3) evaluated memory function (any type) as the outcome measure. In total, 17 articles met the inclusionary criteria. All 17 studies (conducted in rodents) demonstrated that the high-fat diet protocol impaired memory function and all 17 studies demonstrated a counteracting effect with chronic exercise engagement. Mechanisms of these robust effects are discussed herein.

【 授权许可】

Unknown