Inflammatory Mechanisms of Diabetes and Its Vascular Complications

Biomedicines

Yuliya V. Markina¹  Tatiana V. Kirichenko¹  Irina A. Kuzina²  Irina Y. Yudina²  Nina A. Petunina²  Lyudmila V. Nedosugova²  Leyla A. Bochkareva² 

[1] Petrovsky National Research Center of Surgery, 119991 Moscow, Russia;Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia;

关键词: diabetes;    inflammation;    cytokines;    macrophages;    mitochondria;    insulin resistance;   

DOI  :  10.3390/biomedicines10051168

来源: DOAJ

【 摘 要 】

The main cause of death in patients with type 2 DM is cardiovascular complications resulting from the progression of atherosclerosis. The pathophysiology of the association between diabetes and its vascular complications is complex and multifactorial and closely related to the toxic effects of hyperglycemia that causes increased generation of reactive oxygen species and promotes the secretion of pro-inflammatory cytokines. Subsequent oxidative stress and inflammation are major factors of the progression of type 2 DM and its vascular complications. Data on the pathogenesis of the development of type 2 DM and associated cardiovascular diseases, in particular atherosclerosis, open up broad prospects for the further development of new diagnostic and therapeutic approaches.

【 授权许可】

Unknown