High Fat Diet, Metabolic Syndrome and Systemic Lupus Erythematosus: A Causal Loop

Mediterranean Journal of Rheumatology

ARTICLE

Carlo Perricone¹  Fulvia Ceccarelli² 

[1] Dipartimento di Medicina, University of Perugia;Lupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome

关键词: Systemic lupus erythematosus;    TLR;    TLR7;    diet;    metabolic syndrome;    inflammation;    obesity;    insulin resistance;    cytokines;   

DOI  :  10.31138/mjr.31.2.172

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Mechanisms of systemic lupus erythematosus (SLE) exacerbation are still unclear. Several lines of evidence pointed out that metabolic syndrome is a frequent manifestation in SLE patients, with approximately 35% being overweight and another 27% obese.1 Obesity is, per se, a proinflammatory status in which there is an increased gene and protein expression of proinflammatory molecules such as IL-17, IL-23 and TNF-α.2 In childhood-onset SLE, TNF-α levels are associated with obesity and body fat content. It has been observed that obese lupus patients tend to have a have a worsening of their chronic inflammatory status, probably because of increased oxidative stress, increased C-reactive protein expression and elevated protein oxidation and lipid hydroperoxidation.3 The metabolic syndrome (MetS) is recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. It includes several risk factors such as central obesity, insulin resistance, dyslipidaemia, increased blood pressure, and endothelial dysfunction.4 The tissue possibly responsible for these events is the white adipose tissue that becomes dysfunctional and produces excessive amounts of pro-inflammatory soluble mediators including interleukin 6 (IL-6), and adipokines such as leptin, adiponectin, and resistin.

【 授权许可】

CC BY-NC