Pioneer Valley Life Sciences Institute Program in Endocrinology and Metabolism

Schneyer, Alan ; Brown, Melissa ; Schwartz, Lawrence ; Yadava, Nagendra ; and Jerry, D Joseph

关键词: TGFBeta superfamily ligands;    Beta-cell function;    pancreatic islets;    activin A and B proteins;    Beta-cells in islets;    myostatin;    antagonist follistatin like-3 (FSTL3);    Beta-cell proliferation;    transdifferentiation into Beta-cells;    Beta-cell hyperplasia;    myoblasts;    insulin resistance;    extracellular acidification rate;    Facioscapulohumeral Muscular Dystrophy (FSHD);    respiratory activity;    mitochondrial mass;    reactive oxygen species production;    primary pancreatic Beta cells;    Complex I function;    muscle pathophysiology;   

DOI  :  10.2172/1039284
RP-ID  :  DOE/SC0003684
PID  :  OSTI ID: 1039284

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

Specific Aim - To determine the role of TGFBeta superfamily ligands in regulating Beta-cell function, proliferation, and survival (Drs. Schneyer and Brown) Specific Aim - To determine the feasibility of using respiratory activity and extracellular acidification rates of myoblasts to decipher the state of insulin resistance in cultured myoblastsMyoblast physiology (Drs. Schwartz and Yadava)