Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS)

BMC Medicine

William C. Mathews¹  Donald M. Lloyd-Jones²  Matthew J. Feinstein²  Richard D. Moore³  Inga Peter⁴  Susan R. Heckbert⁵  J. A. Chris Delaney⁵  William B. Lober⁵  James H. Willig⁶  Greer A. Burkholder⁶  Michael J. Mugavero⁶  Michael S. Saag⁶  Matthew J. Budoff⁷  Peter W. Hunt⁸  Priscilla Hsue⁸  Carl Grunfeld⁸  Elvin Geng⁸  Sonia Napravnik⁹  Joseph J. Eron⁹  Robin M. Nance^1,10  Daniel R. Drozd^1,10  Heidi M. Crane^1,10  Kristina Crothers^1,10  Mari M. Kitahata^1,10 

[1] Department of Medicine, University of California-San Diego Medical Center;Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine;Johns Hopkins University;Mount Sinai School of Medicine;School of Public Health, University of Washington;University of Alabama-Birmingham School of Medicine;University of California-Los Angeles School of Medicine;University of California-San Francisco School of Medicine;University of North Carolina School of Medicine;University of Washington School of Medicine;

关键词: Human immunodeficiency virus;    Myocardial infarction;    Mortality;    Comorbidity;    Cardiovascular diseases;    Multicenter study;   

DOI  :  10.1186/s12916-019-1385-7

来源: DOAJ

【 摘 要 】

Abstract Background Persons with human immunodeficiency virus (HIV) have higher risks for myocardial infarction (MI) than the general population. This is driven in part by higher type 2 MI (T2MI, due to coronary supply-demand mismatch) rates among persons with HIV (PWH). In the general population, T2MI has higher mortality than type 1 MI (T1MI, spontaneous and generally due to plaque rupture and thrombosis). PWH have a greater burden of comorbidities and may therefore have an even greater excess risk for complication and death in the setting of T2MI. However, mortality patterns after T1MI and T2MI in HIV are unknown. Methods We analyzed mortality after MI among PWH enrolled in the multicenter, US-based Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort (N = 28,186). Incident MIs occurring between January 1, 1996, and December 31, 2014, were centrally adjudicated and classified as T1MI or T2MI. We first compared mortality following T1MI vs. T2MI among PWH. Cox survival analyses and Bayesian model averaging were then used to evaluate pre-MI covariates associated with mortality following T1MI and T2MI. Results Among the 596 out of 28,186 PWH who experienced MI (2.1%; 293 T1MI and 303 T2MI), mortality rates were significantly greater after T2MI (22.2/100 person-years; 1-, 3-, and 5-year mortality 39%, 52%, and 62%) than T1MI (8.2/100 person-years; 1-, 3-, and 5-year mortality 15%, 22%, and 30%). Significant mortality predictors after T1MI were higher HIV viral load, renal dysfunction, and older age. Significant predictors of mortality after T2MI were low body-mass index (BMI) and detectable HIV viral load. Conclusions Mortality is high following MI for PWH and substantially greater after T2MI than T1MI. Predictors of death after MI differed by type of MI, reinforcing the different clinical scenarios associated with each MI type and the importance of considering MI types separately.

【 授权许可】

Unknown