White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection

BMC Research Notes

Alasdair M. Barr⁴  William G. Honer²  G. William MacEwan⁵  Ana Aleksic⁴  Heidi N. Boyda⁴  Tania Lecomte¹  Willough Jenkins⁵  Fidel Vila-Rodriguez⁵  Ric M. Procyshyn²  Taylor Willi²  William J. Panenka²  Chantelle J. Giesbrecht³  Donna J. Lang²  Victor M. Tang⁵ 

[1] Département de Psychologie, Université de Montréal, Montreal, QC, Canada;British Columbia Mental Health & Addictions Research Institute, 938 W 28th Avenue, Vancouver V5Z4H4, Canada;Department of Psychology, Simon Fraser University, 8888 University Drive, Burnaby V5A1S6, Canada;Department of Pharmacology, University of British Columbia, 2176 Health Sciences Mall, Vancouver V6T1Z3, BC, Canada;Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver V6T2A1, Canada

关键词: Psychostimulant;    Neurocognitive;    Magnetic resonance imaging;    Human immunodeficiency virus;    Diffusion tensor imaging;    Comorbidity;   

Others  :  1229552
DOI  :  10.1186/s13104-015-1501-5

 received in 2015-04-14, accepted in 2015-09-21,  发布年份 2015

【 摘 要 】

Background

Psychostimulant drug use is commonly associated with drug-related infection, including the human immunodeficiency virus (HIV). Both psychostimulant use and HIV infection are known to damage brain white matter and impair cognition. To date, no study has examined white matter integrity using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) in chronic psychostimulant users with comorbid HIV infection, and determined the relationship of white matter integrity to cognitive function.

Methods

Twenty-one subjects (mean age 37.5 ± 9.0 years) with a history of heavy psychostimulant use and HIV infection (8.7 ± 4.3 years) and 22 matched controls were scanned on a 3T MRI. Fractional anisotropy (FA) values were calculated with DTI software. Four regions of interest were manually segmented, including the genu of the corpus callosum, left and right anterior limbs of the internal capsule, and the anterior commissure. Subjects also completed a neurocognitive battery and questionnaires about physical and mental health.

Results

The psychostimulant using, HIV positive group displayed decreased white matter integrity, with significantly lower FA values for all white matter tracts (p < 0.05). This group also exhibited decreased cognitive performance on tasks that assessed cognitive set-shifting, fine motor speed and verbal memory. FA values for the white matter tracts correlated with cognitive performance on many of the neurocognitive tests.

Conclusions

White matter integrity was thus impaired in subjects with psychostimulant use and comorbid HIV infection, which predicted worsened cognitive performance on a range of tests. Further study on this medical comorbidity is required.

【 授权许可】

   
2015 Tang et al.

【 图 表 】

Fig.1.

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