N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation â€

Molecules

关键词: Amino acids;    cyclic sulfamides;    cyclization;    Mitsunobu reaction;    propionylation;    constrained peptides.;   

DOI  :  10.3390/10111387

来源: DOAJ

【 摘 要 】

The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.

【 授权许可】

Unknown