Protein Quality Control in Bacterial Cells: Integrated Networks of Chaperones and ATP-Dependent Proteases.

Flanagan, J. M. ; Bewley, M. C.

Technical Information Center Oak Ridge Tennessee

关键词: Proteins;    Cells(Biology);    Bacteria;    Amino acids;    Genetic engineering;   

RP-ID  :  DE200415006567

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

It is generally accepted that the information necessary to specify the native, functional, three-dimensional structure of a protein is encoded entirely within its amino acid sequence; however, efficient reversible folding and unfolding is observed only with a subset of small single-domain proteins. Refolding experiments often lead to the formation of kinetically-trapped, misfolded species that aggregate, even in dilute solution. In the cellular environment, the barriers to efficient protein folding and maintenance of native structure are even larger due to the nature of this process.