Synthesis of Novel Carbovir Analogue

Bulletin of the Korean chemical society

Joon Hee Hong¹  Aihong Kim¹ 

关键词: Antiviral agents;    Branched nucleoside;    Mitsunobu reaction;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The synthesis of 4`-phenyl and 1`-methyl doubly branched carbocyclic nucleoside was accomplished from 2-hydroxy acetophenone. The 4`-phenyl group was installed via a [3,3]-sigmatropic rearrangement reaction, and the carbonyl addition of methylmagnesium bromide was used to introduce the 1`-methyl group. Cyclization of divinyl 9 was performed using 2^nd generation Grubbs catalyst. The coupling of cyclopentenol 12�? with 6-chloropurine by Mitsunobu reaction and desilylation was used to synthesize the target nucleoside 15.

【 授权许可】

Unknown