A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides

Molecules

Amel Bendjeddou¹  Tahar Abbaz¹  Zine Regainia¹ 

[1] ¹Laboratoire de Chimie Organique Appliquée, Groupe de chimie Hétérocyclique, Département de Chimie, Faculté des Sciences, Université d’Annaba, BP 12, 23000, Algérie ²Laboratoire de Chimie des Matériaux Organiques, Université de Tébessa, Route de Constantine, Tébessa, 12000, Algérie

关键词: cyclic sulfamides;    benzodithiazine dioxides;    benzoxathiazepine dioxides;   

DOI  :  10.3390/molecules17021890

来源: mdpi

【 摘 要 】

This work reports the synthesis of novel 1,4,3,5-oxathiadiazepanes 4,4-dioxides from the reaction of N’-benzyl-N-(2-hydroxyethyl)-sarcosine or proline sulfamide with aromatic aldehydes under acid catalysis. To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.