Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells

Stem Cell Research & Therapy

Fangqi Li¹  Yiyong Tang¹  Jingyi Hou¹  Bin Song¹  Menglei Yu¹  Rui Yang¹  Congda Zhang¹  Qingyue Li¹ 

[1] Department of Orthopedic, Sun Yat-sen Memorial Hospital Sun Yat-sen University;

关键词: Synovium;    Synoviocytes;    Fibroblasts;    Mesenchymal stem cells;    MSCs;   

DOI  :  10.1186/s13287-019-1359-x

来源: DOAJ

【 摘 要 】

Abstract Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has long been a topic of debate. The terms “type B synoviocytes,” “fibroblast-like synoviocytes (FLS),” “synovium-derived mesenchymal stem cells (MSCs),” and “synovial fibroblasts (SF)” appeared in different articles related to human synovial-derived cells in various disease models, yet they seemed to be describing the same cell type. However, to date, there is no clear standard to distinguish these terms; thus, the hypothesis that they represent the same cell type is currently inconclusive. Therefore, this review aims to clarify the similarities and differences between these terms and to diffuse the chaotic nomenclature of synovial-derived cells.

【 授权许可】

Unknown