Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation

Redpath, J. Leslie

University of California, Irvine

关键词: 63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;    Fibroblasts;    In Vitro;    Ionizing Radiations;    54 Environmental Sciences;   

DOI  :  10.2172/833322
RP-ID  :  EMSP-69848--2002
RP-ID  :  FG07-99ER62876
RP-ID  :  833322

美国|英语

来源: UNT Digital Library

【 摘 要 】

response curve for radiation-induced neoplastic transformation of HeLa x skin fibroblast human hybrid cells in vitro under experimental conditions where an adaptive response, if it were induced, would have an opportunity to be expressed. During the first two years of the grant an exhaustive series of experiments were performed and the resulting data were reported at the 2000 Annual Meeting of the Radiation Research Society and then subsequently published (Redpath et al., 2001). The data showed that an adaptive response against spontaneous neoplastic transformation was seen up to doses of 10cGy of Cs-137 gamma rays. At dose of 30, 50 and 100 cGy the transformation frequencies were above background. This indicated that for this system, under the specific experimental conditions used, there was a threshold of somewhere between 10 and 30 cGy. The results also indicated some unexpected, though very interesting, correlations with relative risk estimates made from human epidemiologic studies (for details see the Redpath et al., 2001 ).