Microemulsion Based Transdermal Drug Delivery of Labetalol

RGUHS Journal of Pharmaceutical Sciences

P Sahithi¹  Kama Ramesh²  Boggarapu Prakash Rao¹  Beny Baby²  Subramanian Rajarajan² 

[1] Department of Pharmaceutical Technology, Karnataka College of Pharmacy, Bangalore–560 064, Karnataka, India.Department of Pharmaceutical Technology, Karnataka College of Pharmacy, Bangalore–560 064, Karnataka, India.Department of Pharmaceutical Technology, Karnataka College of Pharmacy, Bangalore–560 064, Karnataka, India.;Department of Pharmaceutics, Karnataka College of Pharmacy, Bangalore– 560 064, Karnataka, India.Department of Pharmaceutics, Karnataka College of Pharmacy, Bangalore– 560 064, Karnataka, India.Department of Pharmaceutics, Karnataka College of Pharmacy, Bangalore– 560 064, Karnataka, India.

关键词: Labetalol;    Ex Vivo;    In Vitro;    Globule Size;    Skin Irritation.;   

DOI  :  10.5530/rjps.2014.4.4

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

Purpose: The purpose of the research was to formulate Microemulsion based transdermal drug delivery for a poorly soluble and low bioavailable drug, labetalol, an antihypertensive agent. Methodology: Based on solubility studies Isopropyl myristate, Tween 80 and 1,2-propylene glycol were selected as Oil, Surfactant and Co-surfactant respectively. Pseudo ternary phase studies were carried out. The optimum concentrations for labetalol microemulsion based on phase diagram and thermodynamic stability evaluation were found to be Isopropyl myristate (6.66% w/w), Mixture (36.66% w/w) of 1 part of Tween 80, 15 parts of 1,2-propylene glycol and remaining water. The labetalol microemulsions were prepared by phase titration method. Findings: The globule size, zeta potential, viscosity, in vitro and ex vivo release for the best formulation was found to be 9.826 nm, -15.96 mV, 0.8872 cP, 92.61% and 71.045% respectively. Permeation studies of labetalol microemulsions were performed through rat skin. The steady state flux (Jss) was determined and found to be 4.912 mgcm−2h−1. Conclusion: Based on the responses labetalol microemulsion shows a potential drug delivery system with good stability and release profile.

【 授权许可】

Unknown