Fibroblasts as a practical alternative to mesenchymal stem cells

Journal of Translational Medicine

Santosh Kesari¹  Pete O’Heeron²  Thomas E. Ichim² 

[1] Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute and Pacific Neuroscience Institute;SpinalCyte LLC;

关键词: Stem cell therapy;    Regenerative medicine;    Disc degenerative disease;    Fibroblasts;    Mesenchymal stem cells;   

DOI  :  10.1186/s12967-018-1536-1

来源: DOAJ

【 摘 要 】

Abstract Mesenchymal stem cell (MSC) therapy offers great potential for treatment of disease through the multifunctional and responsive ability of these cells. In numerous contexts, MSC have been shown to reduce inflammation, modulate immune responses, and provide trophic factor support for regeneration. While the most commonly used MSC source, the bone marrow provides relatively little starting material for cellular expansion, and requires invasive extraction means, fibroblasts are easily harvested in large numbers from various biological wastes. Additionally, in vitro expansion of fibroblasts is significantly easier given the robustness of these cells in tissue culture and shorter doubling time compared to typical MSC. In this paper we put forward the concept that in some cases, fibroblasts may be utilized as a more practical, and potentially more effective cell therapy than mesenchymal stem cells. Anti-inflammatory, immune modulatory, and regenerative properties of fibroblasts will be discussed in the context of regenerative medicine.

【 授权许可】

Unknown