Insulin Resistance in Alzheimer's Disease

Frontiers in Neuroscience

Fernanda G. De Felice¹  Laís S. S. Ferreira²  Caroline S. Fernandes²  Marcelo N. N. Vieira³ 

[1] Department of Biomedical and Molecular Sciences, Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada;Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;

关键词: insulin signaling;    insulin resistance;    Alzheimer's disease;    obesity;    type 2 diabetes;    metabolic dysregulation;   

DOI  :  10.3389/fnins.2018.00830

来源: DOAJ

【 摘 要 】

The epidemiological connection between diabetes, obesity, and dementia represents an important public health challenge but also an opportunity to further understand these conditions. The key intersection among the three diseases is insulin resistance, which has been classically described to occur in peripheral tissues in diabetes and obesity and has recently been shown to develop in Alzheimer's disease (AD) brains. Here we review encouraging preclinical and clinical data indicating the potential of targeting impaired insulin signaling with antidiabetic drugs to treat dementia. We further discuss biological mechanisms through which peripheral metabolic dysregulation may lead to brain malfunction, providing possible explanations for the connection between diabetes, obesity, and AD. Finally, we briefly discuss how lifelong allostatic load may interact with aging to increase the risk of dementia in late life.

【 授权许可】

Unknown