White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Food & Nutrition Research

Lie-Fen Shyur¹  Shu-Fang Lo²  Chiao-Ming Chen³  Peng-Ru Chen³  Chun-Kuang Shih⁴  Sing-Chung Li⁴  Viola Varga⁴  Liang-Chen Shih⁴ 

[1] Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan;Department of Agronomy, Chiayi Agricultural Experiment Station, Taiwan Agricultural Research Institute, Chiayi, Taiwan;Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei, Taiwan;School of Nutrition and Health Science, College of Nutrition, Taipei Medical University, Taipei, Taiwan;

关键词: white sweet potato;    antidiabetic;    antihyperglycemic;    pancreatic islets;    insulin sensitivity;   

DOI  :  10.29219/fnr.v64.3609

来源: DOAJ

【 摘 要 】

Background: White sweet potato (WSP) has many potential beneficial effects on metabolic control and on diabetes-related insulin resistance. The antihyperglycemic effects of Tainung No. 10 (TNG10), a variety of WSP in Taiwan, warrant investigation. Objective: To investigate the antidiabetic activity of WSP (Ipomoea batatas L. TNG10) and the mechanisms for interventions using whole leaves or tubers of WSP in diabetic mice. Design: Mice were co-administered with streptozotocin and nicotinamide to induce diabetes and then treated with an experimental diet including either 10% WSP tuber (10%-T) and 30% WSP tuber (30%-T) or 0.5% WSP leaf (0.5%-L) and 5% WSP leaf (5%-L). After 8 weeks’ treatment, their plasma glycemic parameters, lipid profiles, and inflammatory marker were analyzed. Their pancreases were removed for histopathologic image analysis; proteins were also extracted from their muscles for phosphoinositide 3-kinase pathway analysis. Results: The 30%-T or 5%-L mice had lower plasma glucose, insulin, glucose area under the curve (AUC), homeostatic model assessment of insulin resistance (HOMA-IR), alanine transaminase, triglyceride, and tumor necrosis factor alpha levels. In all diabetic mice, their Langerhans’s area was reduced by 60%; however, after 30% WSP-T or 5% WSP-L diets, the mice demonstrated significant restoration of the Langerhans’s areas (approximately 30%). Only in 5%-L mice, slightly increased expression of insulin-signaling pathway-related proteins, phosphorylated insulin receptor and protein kinase B and membrane glucose transporter 4 was noted. Conclusions: WSP has antihyperglycemic effects by inducing pancreatic islet regeneration and insulin resistance amelioration. Therefore, WSP has potential applications in dietary diabetes management.

【 授权许可】

Unknown