Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Frontiers in Endocrinology

Isa Naina Mohamed¹  Chao Zhao²  Shah Alam Khan³  Jianbo Xiao⁴  Mohammad A. Rashid⁵  Nusrat Islam Chaity⁶  Safaet Alam⁶  Taposhi Nahid Sultana⁷  Md. Nafees Rahman Chowdhury⁸  Md. Moklesur Rahman Sarker⁹  Elsayed E. Hafez^1,10 

[1] Technology, Muscat, Oman;College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China;;College of Pharmacy, National University of Science &Department of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo, Vigo, Spain;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh;Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh;Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh;Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh;Pharmacology and Toxicology Research Division, Health Med Science Research Limited, Dhaka, Bangladesh;Plant Protection and Biomolecular Diagnosis Department, ALCRI (Arid Lands Cultivation Research Institute), City of Scientific Research and Technological Applications, Alexandria, Egypt;

关键词: diabetes mellitus;    antidiabetic;    antihyperglycemic;    phytochemical;    phytomedicine;    bioactive compound;   

DOI  :  10.3389/fendo.2022.800714

来源: DOAJ

【 摘 要 】

Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several in vitro, in vivo, and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics.

【 授权许可】

Unknown