Glycemic Control Potential of Chemically Characterized Extract from Withania frutescens L. Roots in Severe Diabetes-Induced Mice

Applied Sciences

HebaKhalil Alyahya¹  MohammedSaeed Alkaltham¹  AhmadMohammad Salamatullah¹  Hamza Mechchate²  Imane Es-safi²  Dalila Bousta²  Abdelfattah El Moussaoui²  Amina Bari²  Mohammed Bourhia³ 

[1] Department of Food Science & Nutrition, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia;Laboratory of Biotechnology, Environment, Agrifood, and Health, Faculté of science-Fez, University of Sidi Mohamed Ben Abdellah, Fez 30050, Morocco;Laboratory of Chemistry, Biochemistry, Nutrition, and Environment, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca 20000, Morocco;

关键词: Withania frutescens L.;    roots;    diabetes mellitus;    glibenclamide;    antidiabetic;    antihyperglycemic;   

DOI  :  10.3390/app11093998

来源: DOAJ

【 摘 要 】

Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from Withania frutescens L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, Withania frutescens L. can serve society as it provides natural agents to control diabetes.

【 授权许可】

Unknown