The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data

Animals

Maria Pia Pasolini¹  ChiaraDel Prete¹  Luigi Auletta²  Adelaide Greco³  Leonardo Meomartino³  Pierpaolo Coluccia³  Dario Costanza³  Chiara Montano⁴ 

[1] Department of Veterinary Medicine and Animal Production, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, Italy;Institute of Biostructure and Bioimaging, National Research Council (IBB CNR), Via T. De Amicis 95, 80145 Napoli, Italy;Interdepartmental Centre of Veterinary Radiology, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, Italy;Veterinary Teaching Hospital, School of Veterinary Medicine, University of Córdoba, 14004 Córdoba, Spain;

关键词: DDFT;    equine;    growth factors;    healing;    ligament;    platelet concentrate;   

DOI  :  10.3390/ani11030793

来源: DOAJ

【 摘 要 】

The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.

【 授权许可】

Unknown