Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective study

Radiation Oncology

Osamu Fujii¹  Tomohiro Yamashita²  Masaki Suga²  Takashi Akagi²  Tomoaki Okimoto³  Masayuki Mima³  Nobukazu Fuwa³  Yusuke Demizu³  Fumiko Nagano³  Kazuki Terashima³  Kuniaki Katsui⁴  Koh-ichi Sakata⁵  Masaru Takagi⁶  Dongcun Jin⁷  Yasue Niwa⁷ 

[1] Department of Radiation Oncology, Hakodate Goryoukaku Hospital;Department of Radiation Physics, Hyogo Ion Beam Medical Center;Department of Radiology, Hyogo Ion Beam Medical Center;Department of Radiology, Okayama University;Department of Radiology, Sapporo Medical University;Proton Therapy Center, Sapporo Teishinkai Hospital;Proton Therapy Center, Tsuyama Chuo Hospital;

关键词: Skull base chordoma;    Proton therapy;    Carbon ion therapy;    Radiotherapy;    Surgery;    Local control;   

DOI  :  10.1186/s13014-018-1173-0

来源: DOAJ

【 摘 要 】

Abstract Background The usefulness of particle therapy for skull base chordoma has not been established. The aim of this retrospective study was to analyse the treatment outcomes of proton therapy (PT) and carbon ion therapy (CIT) in patients with skull base chordoma at a single institution. Methods All patients who underwent PT or CIT with curative intent between 2003 and 2014 at Hyogo Ion Beam Medical Center were included in this study. Twenty-four patients were enrolled. Eleven (46%) received PT and 13 (54%) received CIT. Overall survival (OS), progression-free survival (PFS) and local control (LC) were calculated using the Kaplan–Meier method. Late toxicities were evaluated according to the Common Terminology Criteria for Adverse Events version 4.0. Results The median follow-up was 71.5 months (range, 14–175 months). The five-year LC, PFS and OS rates were 85, 81, and 86%, respectively. The LC (P = 0.048), PFS (P = 0.028) and OS (P = 0.012) were significantly improved in patients who had undergone surgery before particle therapy. No significant differences were observed in the LC rate and the incidence of grade 2 or higher late toxicities between patients who received PT and CIT. Conclusions Both PT and CIT appear to be effective and safe treatments and show potential to become the standard treatments for skull base chordoma. To increase the local control, surgery before particle therapy is preferable.

【 授权许可】

Unknown