Effects of charged particles on human tumor cells

Frontiers in Oncology

Hidemasa eKawamura¹  Yukari eYoshida²  Akihisa eTakahashi²  Athena Evalour S. Paz²  Takuya eKaminuma³  Kathryn D Held³  Henning eWillers³  Qi eLiu³ 

[1] Gunma University Graduate School of Medicine;Gunma University Heavy Ion Medical Center;Massachusetts General Hospital/Harvard Medical School;

关键词: Hypofractionation;    Proton therapy;    cancer stem cells (CSCs);    charged particles;    Carbon ion therapy;    relative biological effectiveness (RBE);   

DOI  :  10.3389/fonc.2016.00023

来源: DOAJ

【 摘 要 】

The use of charged particle therapy in cancer treatment is growing rapidly, in large part because the exquisite dose localization of charged particles allows for higher radiation doses to be given to tumor tissue while normal tissues are exposed to lower doses and decreased volumes of normal tissues are irradiated.In addition, charged particles heavier than protons have substantial potential clinical advantages because of their additional biological effects including greater cell killing effectiveness, decreased radiation resistance of hypoxic cells in tumors and reduced cell cycle dependence of radiation response.These biological advantages depend on many factors such as endpoint, cell or tissue type, dose, dose rate or fractionation, charged particle type and energy, and oxygen concentration.This review summarizes the unique biological advantages of charged particle therapy and highlights recent research and areas of particular research needs, such as quantification of Relative Biological Effectiveness (RBE) for various tumor types and radiation qualities, role of genetic background of tumor cells in determining response to charged particles, sensitivity of cancer stem-like cells to charged particles, role of charged particles in tumors with hypoxic fractions and importance of fractionation, including use of hypofractionation, with charged particles.

【 授权许可】

Unknown