What does large randomized trials tell us about the fractionation sensitivity of prostate cancer?

Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy

HØyer, M.^1

Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus C

8000, Denmark^1

关键词: Conventional fractionations;    Cost effective;    Hypofractionation;    Localized prostate cancer;    Prostate cancers;    Randomized clinical trials;    Randomized trial;    Sensitivity parameters;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/777/1/012024/pdf
DOI  :  10.1088/1742-6596/777/1/012024

来源: IOP

【 摘 要 】

Seven randomized clinical trials have tested the use of moderate hypofractionation (2.1-3.5 Gy per fraction) compared to conventional fractionation (1.8-2.0 Gy per fraction) in radiotherapy for localized prostate cancer. The trails find that moderate hypofractionation results in acceptable PSA-control and morbidities that are comparable to conventional fractionation schedules. Extrapolation of the results from the earliest randomized trials indicated a low α/β- values for prostate cancer, but the more recent - and large - studies suggest that the value is moderately or considerably higher. Moderate hypofractionation schedules (ie. 20 x 3 Gy) are now being implemented in routine practice. They are cost-effective and convinient, but they are not consistantly concordant with fractionation sensitivity parameters extrapolated from clinical trials on moderate hypofractionation of prostate cancer.