Interdisciplinary Tasks in the Cyclotron Production of Radiometals for Medical Applications. The Case of 47Sc as Example

Molecules

Valentina Costa¹  Antonella Pagnoni¹  Alessandra Boschi²  Licia Uccelli²  Petra Martini² 

[1] Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari, 46-44121 Ferrara, Italy;Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari, 46-44121 Ferrara, Italy;

关键词: radiometals;    cyclotron;    target;    automation;    radiochemical separation;   

DOI  :  10.3390/molecules24030444

来源: DOAJ

【 摘 要 】

The growing number of cyclotrons of different sizes installed in the territory has given a strong impulse to the production of conventional and emerging radionuclides for medical applications. In particular, the great advantage of using medical cyclotrons is the possibility to produce on-site, when needed (on-demand), with medical radionuclides of interest encouraging the personalized medicine approach. Radiometals satisfy the ideal characteristics that radionuclides should have for routine employment in nuclear medicine, especially since they have a robust chemistry suitable to synthetize stable in vivo radiopharmaceuticals with high radiochemical yields. In this letter several interdisciplinary aspects involved in the radiometals cyclotron production cycle are summarized focusing the attention on cyclotron production facilities, target material, and chemical processing available for medical applications. As an example, the current status and recent development in the production of the theranostic radionuclide scandium-47 have been reported.

【 授权许可】

Unknown