Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers

Jurisson, Silvia S.¹  Lever, Susan Z.¹  Robertson, J. David¹ 

[1] Univ. of Missouri, Columbia, MO (United States)

关键词: radiotracer uptake;    radiotracer transport;    plant imaging;    radiometals;    fluorine-18 labeled sucrose;   

DOI  :  10.2172/1327823
RP-ID  :  DOE-MU--2040-1
PID  :  OSTI ID: 1327823

学科分类：化学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers that will be radiolabeled with ¹⁸F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.