Oncogene mRNA Imaging with Radionuclide-PNA-Peptides

Wickstrom, Eric

关键词: 07 ISOTOPES AND RADIATION SOURCES;    COPPER 64;    GENES;    HYBRIDIZATION;    MAMMARY GLANDS;    MICE;    NEOPLASMS;    ONCOGENES;    POSITRONS;    PROBES;    RADIOISOTOPES hybridization;    gamma;    oligonucleotides;    positrons;    radiometals;    transcripts;   

DOI  :  10.2172/925560
RP-ID  :  None
PID  :  OSTI ID: 925560
Others  :  TRN: US1002547

学科分类：核物理和高能物理

美国|英语

来源: SciTech Connect

【 摘 要 】

New cancer gene hybridization probes to carry radionuclides were made. Noninvasive technetium-99m gamma imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated, followed by noninvasive technetium-99m imaging of MYC cancer gene activity. Noninvasive imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated with a positron-emitting copper-64 probe, followed by noninvasive positron imaging of IRS1 cancer gene activity.