High Capacity Heat Exchangers for Recirculating 18F Radionuclide Production Targets

cyclotron;radiopharmaceuticals;radioisotope production;18F anion;2-deoxy-2-[18F]fluoro-D-glucose;High power density heat exchangers;high efficiency heat exchangers;18FDG

Newnam, Robert Pruett ; J.M. Doster, Committee Chair,T. Gerig, Committee Member,M. Haider, Committee Member,B. Wieland, Committee Member,M. Bourham, Committee Member,Newnam, Robert Pruett ; J.M. Doster ; Committee Chair ; T. Gerig ; Committee Member ; M. Haider ; Committee Member ; B. Wieland ; Committee Member ; M. Bourham ; Committee Member

University:North Carolina State University

关键词: cyclotron;    radiopharmaceuticals;    radioisotope production;    18F anion;    2-deoxy-2-[18F]fluoro-D-glucose;    High power density heat exchangers;    high efficiency heat exchangers;    18FDG;   

Others  :  https://repository.lib.ncsu.edu/bitstream/handle/1840.16/2210/etd.pdf?sequence=1&isAllowed=y

美国|英语

来源: null

【 摘 要 】

North Carolina State University in conjunction with Bruce Technologies Inc. is developing recirculating water targets for the cyclotron production of high yields of 18F fluoride for PET radiopharmaceuticals.Flourine-18 is commonly produced through proton irradiation of 18O enriched water by the 18O(p,n)18F reaction.Heat deposited in the target fluid by the proton beam is proportional to the 18F produced, thus production is often limited by the targets ability to reject heat.For power levels above 3 kW, boiling batch targets with local cooling can become impractical due to excessive 18O water volumes.One potential solution is a recirculating target system where the target water velocity is sufficient to prevent boiling.In this design the heated fluid travels through an external heat exchanger of sufficient capacity to remove the heat, and then through a pump which returns the cooled fluid to the target.A high-flow/low-volume pump and a high-capacity/low-volume heat exchanger are essential to the overall performance of the recirculating target.In this work, two different types of heat exchangers are considered.Laboratory testing was conducted on a small shell and tube heat exchanger that removed nearly 6 kW of heat at flows provided by a miniature regenerative turbine pump.Laboratory testing was also conducted on a small cross flow heat exchanger with measured performance of 7.4 kW and predicted peak performance approaching 10 kW.