Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions

Molecules

Md. Saiful Islam¹  Mughal Qayum²  Umer Rashid³  Ihsan Ali⁴  Muhammad Nisar⁴  Muhammad Raza Shah⁵  Muhammad Zia-Ul-Haq⁶ 

[1] Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;Department of Pharmacy, Kohat University of Science and Technology, Kohat-26000, Pakistan;Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan;Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;The Patent Office, Karachi 74400, Pakistan;

关键词: solvent free;    5,5-dimethylcyclohexan-1,3-dione;    PPA-SiO2;    β-enaminones;   

DOI  :  10.3390/molecules181215182

来源: DOAJ

【 摘 要 】

An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO2 as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional groups present on both aromatic and aliphatic amines. In addition, the methodology is environmentally benign and cost-effective due to absence of solvent and easy work-up.

【 授权许可】

Unknown