期刊论文详细信息
Bulletin of the Korean chemical society | |
Silica Gel-Supported Polyphosphoric Acid (PPA-SiO2) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction | |
Niloofar Tavakoli Hoseini1  Majid M. Heravi1  Mohsen Zeinali Dastmalbaf1  Hassan Ali Zamani1  Amir Khojastehnezhad1  Abolghasem Davoodnia1  | |
关键词: Biginelli reaction; Heterogeneous catalysis; PPA-SiO2; Multi-component reactions; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-SiO2) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010242801ZK.pdf | 246KB | download |