PHTHALIC ACID: A GREEN, BIODEGRADABLE AND ENVIRONMENTALLY BENIGN NATURE DI-FUNCTIONAL BRØNSTED ACID CATALYST FOR THE ONE-POT SYNTHESIS OF 3, 4-DIHYDROPYRIMIDIN-2- (1H)-ONE DERIVATIVES AND SUBSTITUTED DIHYDRO-2-OXYPYRROLES

Journal of The Chilean Chemical Society

Mohamadpour, Farzaneh¹  Lashkari, Mojtaba² 

[1] University of Sistan and Baluchestan, Zahedan, Iran;Velayat University, Iranshahr, Iran

关键词: Phthalic acid;    3;    4-Dihydropyrimidinone;    Substituted dihydro-2-oxypyrrole;    Biodegradable green catalyst;    Multi-component reactions;    Green chemistry.;   

DOI  :  10.4067/s0717-97072018000103811

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Phthalic acid as a green, biodegradable economical and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives via β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions and one-pot four-component domino condensation of substituted dihydro-2-oxypyrrole by reaction of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with short reaction times and excellent yields is reported. The most benefits this procedure are such as green, biodegradable, inexpensive and non-toxic catalyst, eco-friendly, high catalytic activity, efficient, easily separation with no column chromatographic separation, simple operational procedures, one-pot, excellent yields, environmentally benign nature.

【 授权许可】

Unknown