Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions

Molecules

Muhammad Nisar⁵  Ihsan Ali⁵  Muhammad Raza Shah³  Mughal Qayum⁴  Muhammad Zia-Ul-Haq¹  Umer Rashid² 

[1] The Patent Office, Karachi 74400, Pakistan; E-Mail:;Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; E-Mail:;Department of Pharmacy, Kohat University of Science and Technology, Kohat-26000, Pakistan;Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan; E-Mail:

关键词: solvent free;    5;    5-dimethylcyclohexan-1;    3-dione;    PPA-SiO₂;    β-enaminones;   

DOI  :  10.3390/molecules181215182

来源: mdpi

【 摘 要 】

An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO₂ as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional groups present on both aromatic and aliphatic amines. In addition, the methodology is environmentally benign and cost-effective due to absence of solvent and easy work-up.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.