The TATA-box motif and its impact on transcriptional gene regulation by miRNAs

Biomolecular Concepts

Aquino-Jarquin Guillermo¹  Granados-Riveron Javier T.¹ 

[1] Laboratorio de Investigación en Genómica, Genética y Bioinformática, Torre de Hemato-Oncología, 4to Piso, Sección 2, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, Col. Doctores, Delegación: Cuauhtémoc, C.P. 06720, México D.F., Mexico;

关键词: ago proteins;    chromatin;    mirnas;    tata-box motif;    transcriptional gene regulation;   

DOI  :  10.1515/bmc-2015-0004

来源: DOAJ

【 摘 要 】

Emerging evidence suggests that components of the small RNAs pathway interact with chromatin to regulate nuclear events, such as gene transcription. However, it has recently been reported that in some cases, gene transcription regulation by cellular miRNAs can occur via targeting the TATA-box motif without altering epigenetic modifications. This observation supports the notion that multiple mechanisms of miRNA-based transcriptional regulation exist, enhancing our understanding of the complexity of small RNA-mediated gene regulatory pathways. Here, we remark that miRNA-mediated transcriptional modulation, through the TATA-box motif, may be a synergistic approach for transcriptional control.

【 授权许可】

Unknown