Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases

International Journal of Molecular Sciences

MarinaC. Costa¹  FranciscoJ. Enguita¹  AndréF. Gabriel¹ 

[1] Instituto de Medicina, Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal;

关键词: non-coding rna;    circrnas;    mirnas;    cardiovascular diseases;    rna regulatory networks;   

DOI  :  10.3390/ijms21020456

来源: DOAJ

【 摘 要 】

Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation capabilities such as the heart. The role of regulatory networks mediated by non-coding RNAs in the pathophysiology of cardiovascular conditions is starting to be unveiled. However, a deeper knowledge of the functional interactions among the diverse non-coding RNA families and their phenotypic consequences is required. This review presents the current knowledge about the functional crosstalk between circRNAs and other biomolecules in the framework of the cardiovascular diseases.

【 授权许可】

Unknown