Role of microRNAs in the Regulation of Dendritic Cell Generation and Function

International Journal of Molecular Sciences

Grazia Serino¹  Marina Liso¹  Viviana Scalavino¹ 

[1] National Institute of Gastroenterology “S. de Bellis”, Research Hospital, 70013 Castellana Grotte (Bari), Italy;

关键词: dendritic cells;    mirnas;    inflammation;   

DOI  :  10.3390/ijms21041319

来源: DOAJ

【 摘 要 】

Dendritic cells (DCs) are antigen-presenting cells with a key role in immune responses. They act as a link between the innate and adaptive systems and they can induce and maintain immunologic tolerance. DCs are subdivided into conventional and plasmacytoid DCs. These cell subsets originate from the same bone marrow precursors and their differentiation process is determined by several extrinsic and intrinsic factors, such as cytokines, transcription factors, and miRNAs. miRNAs are small non-coding RNAs that play a crucial role in modulating physiological and pathological processes mediated by DCs. miRNA deregulation affects many inflammatory conditions and diseases. The aim of this review was to underline the importance of miRNAs in inflammatory processes mediated by DCs in physiological and pathological conditions and to highlight their potential application for future therapies.

【 授权许可】

Unknown