Unwinding BRAHMA Functions in Plants

Genes

Gilles Vachon¹  Marie Le Masson¹  Xuelei Lai¹  Caroline Thouly¹  CristelC. Carles¹ 

[1] Université Grenoble Alpes, unité de formation et de recherche de Chimie et Biologie, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAe), Centre National de la Recherche Scientifique (CNRS), Commissariat à l’énergie atomique et aux énergies alternatives (CEA), Institut de recherche interdisciplinaire de Grenoble (IRIG), Laboratoire de Physiologie Cellulaire et Végétale, 38000 Grenoble, France;

关键词: brahma;    swi2/snf2;    chromatin;    transcription factor;    remodeling;    mirnas;   

DOI  :  10.3390/genes11010090

来源: DOAJ

【 摘 要 】

The ATP-dependent Switch/Sucrose non-fermenting (SWI/SNF) chromatin remodeling complex (CRC) regulates the transcription of many genes by destabilizing interactions between DNA and histones. In plants, BRAHMA (BRM), one of the two catalytic ATPase subunits of the complex, is the closest homolog of the yeast and animal SWI2/SNF2 ATPases. We summarize here the advances describing the roles of BRM in plant development as well as its recently reported chromatin-independent role in pri-miRNA processing in vitro and in vivo. We also enlighten the roles of plant-specific partners that physically interact with BRM. Three main types of partners can be distinguished: (i) DNA-binding proteins such as transcription factors which mostly cooperate with BRM in developmental processes, (ii) enzymes such as kinases or proteasome-related proteins that use BRM as substrate and are often involved in response to abiotic stress, and (iii) an RNA-binding protein which is involved with BRM in chromatin-independent pri-miRNA processing. This overview contributes to the understanding of the central position occupied by BRM within regulatory networks controlling fundamental biological processes in plants.

【 授权许可】

Unknown