Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription

Biology

Jared S. Stees¹  Fred Varn¹  Suming Huang¹  John Strouboulis² 

[1] Department of Biochemistry and Molecular Biology, College of Medicine, Genetics Institute, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA; E-Mails:;Institute of Molecular Oncology, BSRC Alexander Fleming, Varkiza, 16002, Greece; E-Mail:

关键词: gene regulation;    chromatin;    transcription factor;    noncoding RNA;    histone modifications;    enhancer;    promoter;   

DOI  :  10.3390/biology1030778

来源: mdpi

【 摘 要 】

Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.