Bio-Inspired Nanostructured Ti-6Al-4V Alloy: The Role of Two Alkaline Etchants and the Hydrothermal Processing Duration on Antibacterial Activity

Nanomaterials

Neethu Ninan¹  Dennis Palms¹  Krasimir Vasilev¹  Richard Bright¹  Jonathan Wood¹  Anouck Burzava¹  Andrew Hayles¹  Dan Barker²  Toby Brown²  Rahul M. Visalakshan³ 

[1] Academic Unit of STEM, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Australia;Corin Australia, Sydney, NSW 2153, Australia;Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA;

关键词: antibacterial;    biofilm;    biomimetic;    nanostructure;    titanium alloy;    implant associated infection;   

DOI  :  10.3390/nano12071140

来源: DOAJ

【 摘 要 】

Inspired by observations that the natural topography observed on cicada and dragonfly wings may be lethal to bacteria, researchers have sought to reproduce these nanostructures on biomaterials with the goal of reducing implant-associated infections. Titanium and its alloys are widely employed biomaterials with excellent properties but are susceptible to bacterial colonisation. Hydrothermal etching is a simple, cost-effective procedure which fabricates nanoscale protrusions of various dimensions upon titanium, depending on the etching parameters used. We investigated the role of etching time and the choice of cation (sodium and potassium) in the alkaline heat treatment on the topographical, physical, and bactericidal properties of the resulting modified titanium surfaces. Optimal etching times were 4 h for sodium hydroxide (NaOH) and 5 h for potassium hydroxide (KOH). NaOH etching for 4 h produced dense, but somewhat ordered, surface nanofeatures with 75 nanospikes per µm². In comparison, KOH etching for 5 h resulted sparser but nonetheless disordered surface morphology with only 8 spikes per µm². The NaOH surface was more effective at eliminating Gram-negative pathogens, while the KOH surface was more effective against the Gram-positive strains. These findings may guide further research and development of bactericidal titanium surfaces which are optimised for the predominant pathogens associated with the intended application.

【 授权许可】

Unknown